Validated Determination of Meloxicam in Tablets by Using UV Spectrophotometry
نویسنده
چکیده
Meloxicam (MEL) (4-hydroxy-2-methyl-N-(5-methyl-2-thiazoly)-2H1,2-benzo-thiazine-3-carboxamide-1,1dioxide) (C14H13N3O4S2) (Figure 1) is a non-steroidal anti-inflammatory drug (NSAID) 1,2. MEL is a novel NSAIDs with a favorable COX-2 (cyclooxgenase-2): COX-1 (cyclooxgenase-1) selectivity has also been shown to have potent anti-inflammatory effects 3,4. Because of very low solubility of MEL in acidic medium, it may cause local gastrointestinal adverse events 5. Hacettepe University, Journal of Faculty of Pharmacy Volume 24 / Number 1 / January 2004 / pp. 13-24
منابع مشابه
Comparison of classic and derivative UV spectrophotometric methods for quantification of meloxicam and mefenamic acid in pharmaceutical preparations.
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